Cervical cancer is the growth of abnormal cells in the lining of the cervix. The most common cervical cancer is squamous cell carcinoma, accounting for 80% of cases. Adenocarcinoma is less common and more difficult to diagnose because it starts higher in the cervix.
There were 813 new cases of cervical cancer diagnosed in Australia in 2013. The risk of a woman being diagnosed by age 85 is 1 in 168.
In Australia, the five year survival rate for women diagnosed with cervical cancer is 72%.
In 2014, there were 223 deaths caused by cervical cancer in Australia. Cervical cancer death rates in Australia have halved since the National Cervical Screening Program began in 1991.
Early changes in cervical cells rarely cause symptoms. If early cell changes develop into cervical cancer, the most common signs include:
- vaginal bleeding between periods
- menstrual bleeding that is longer or heavier than usual
- bleeding after intercourse
- pain during intercourse
- unusual vaginal discharge
- vaginal bleeding after menopause
- excessive tiredness
- leg pain or swelling
- low back pain.
Almost all cases of cervical cancer are caused by persistent infection with some high-risk types of the human papillomavirus (HPV); this is the biggest risk factor for cervical cancer. The other main risk factor for cervical cancer is smoking.
Around eight out of 10 women will become infected with genital HPV at some time in their lives. Most women who have the HPV infection never get cervical cancer; only a few types of the HPV result in cervical cancer.
Women exposed to diethylstilbestrol (an artificial form of female hormone oestrogen) in utero are at increased risk of cervical cancer. You can read more about this here.
The usual tests to diagnose cervical cancer are:
A colposcopy identifies where abnormal cells are located in the cervix, and what they look like. A speculum is inserted into your vagina so that the doctor can view the cervix and vagina via a colposcope, an instrument that magnifies the area, like binoculars. It is not put inside your body.
Biopsy, cone biopsy or large loop excision of the transformation zone
A biopsy is when the doctor removes some tissue from the surface of the cervix and sends it to a laboratory for examination under a microscope. The biopsy may be done during the colposcopy.
If cervical cancer is detected, it will be ‘staged’, from stage 0, which means abnormal cells are found only in the surface layer of cells lining the cervix to stage IV, which means the cancer has spread to nearby organs such as the bladder or rectum or possibly other organs. This helps your doctors plan the best treatment for you.
Types of treatment
Treatment depends on disease stage. For early and non bulky disease (less than 4cm), treatment is surgery, sometimes with chemoradiotherapy afterwards.
If the tumour is small, a cone biopsy may suffice; in some cases hysterectomy (surgical removal of the uterus) is required.
For locally advanced disease, a combination of radiotherapy and chemotherapy (cisplatin) is used.
For metastatic disease, the treatment is chemotherapy (platinum/fluorouracil) or palliative care alone.
In some cases of cervical cancer, your medical team may talk to you about palliative care. Palliative care aims to improve your quality of life by alleviating symptoms of cancer.
As well as slowing the spread of cervical cancer, palliative treatment can relieve pain and help manage other symptoms. Treatment may include radiotherapy, chemotherapy or other drug therapies.
Initial test will be arranged by your GP who will also be part of your overall treatment team. Depending on your treatment, your treatment team may consist of a number of different specialist staff, such as:
- a gynaecologist
- a gynaecological oncologist
- a radiation oncologist
- a medical oncologist
- a cancer care coordinator
- a dietician
- other allied health professionals, such as a psychologist and physiotherapists.
The National Cervical Screening Program currently recommends all women aged between 18 and 70 who have ever been sexually active have regular Pap tests. Women should start having Pap tests every two years from 18-20 years of age, or one to two years after sexual activity commences, whichever is later.
From late 2017, the pap smear test will be replaced with an HPV test. Women aged 25-74 will be tested every five years. This will be part of the National Cervical Screening Program
It is not possible for a doctor to predict the exact course of a disease, as it will depend on each person’s individual circumstances. However, your doctor may give you a prognosis, the likely outcome of the disease, based on the type of cervical cancer you have, the test results, the rate of tumour growth, as well as your age, fitness and medical history.
Cervical cancer can be effectively treated when it is found early. Most women with early cervical cancer will be cured.
Treatment for cervical cancer may make it more difficult, or impossible, to become pregnant. If fertility is important to you, talk to you doctor before treatment commences.
A vaccine has been developed that prevents the types of HPV most commonly linked to cervical cancer. The vaccines currently available in Australia are Gardasil and Cervarix. Through the National Immunisation Program, most girls in Australia will receive the HPV vaccine around the age of 12. Since 2013, boys have also been included in the National HPV Immunisation Program because the vaccine also helps prevent some HPV-related cancers and disease that affect men. Find out more about the HPV vaccine here.
Understanding Cervical Cancer, Cancer Council Australia, ©2015. Last medical review of this booklet: Oct 2015.
Australian Institute of Health and Welfare. ACIM (Australian Cancer Incidence and Mortality) Books. Canberra: AIHW.
Australian Institute of Health and Welfare (AIHW) 2017. Cancer in Australia 2017. Cancer series no. 101. Cat. no. CAN 100. Canberra: AIHW.